The D614G mutation in SARS-CoV-2 is infamous for its rising dominance worldwide. This mutation changes the amino acid at position 614, from D (aspartic acid) to G (glycine) — so, D-614-G.
A genetic mutation is characterized by a permanent change in the DNA sequence that may occur due to environmental factors (UV radiation), or due to an error during DNA replication process. D614G mutation in the viral spike protein occurred at the initial stage of the pandemic, and recent evidence suggests that viruses containing glycine residue at position 614 have now become the most prevalent variant globally.
Using suitable bioinformatic methods, scientists have found that G614G mutation in the viral spike protein is the most frequently occurring mutation across many geographical locations. As pseudotyped viruses, G614 variants have considerably higher infectious titers than D614 variants. This indicates that spike D614G mutation makes the novel coronavirus more infectious and that the virus can be transmitted more easily and rapidly from person to person.